Talk:Acromegaly

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Visible on thep page now Mozzerati 14:15, 2004 May 16 (UTC)

Statistics on Acromegaly prevalence?

I heard that Acromegaly is about 50 cases per million at any given time, but it would be nice to have some concrete stats here.

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A 2004 study showed a vastly higher prevalence: http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15274075 It seems as if acromegaly is extremely rarely diagnosed. —Preceding unsigned comment added by 77.0.229.236 (talk) 16:59, 17 January 2008 (UTC)

And what's the geographical distribution, if any? I think the ancient Romans probably called it the Morbus Campanus (countryside disease) and I've seen it in at least one or two Italian movies set in the Sicilian countryside. — Preceding unsigned comment added by 86.152.151.189 (talk) 12:38, 13 December 2014 (UTC) I believe except for one valley in Belgium, there has not been a geographical distribution found.--CSvBibra (talk) 18:28, 13 December 2014 (UTC)

Acromegaly patients are not abnormally tall

By definition, acromegaly is the clinical picture of a patient with high circulating levels of growth hormones following the closure of epiphyseal (growth) plates, and hence are of normal height. I am therefore highly suspicious of the claims that famous tall people had acromegaly (instead, they are more likely to have had pubertal giantism.

You write as if human growth in height normally ceases at puberty (when the epphyseal plates close). Rediculous. 64.71.2.189 (talk) 21:23, 20 March 2012 (UTC)

Since lay people assume that acromegaly causes giantism, please add text to the article linking to more common hormonal causes of giantism. The Notable People section makes no distinction, and combines normal-sized people and giants. Mdmcginn (talk) 18:11, 9 October 2022 (UTC)

Please use the metric system

In the "Notable sufferers" section, all heights are shown in feet/inches. As this is an international website, please always use, or at least indicate the equivalent, metric units. Thank you. —The preceding unsigned comment was added by Byron.calisto (talk • contribs) 05:48, 14 December 2006 (UTC).

Do you think that, if we all try to use metric measures, they might catch on? --OhNoPeedyPeebles (talk) 15:52, 25 October 2008 (UTC)

A penny to a pint they won't. --OhNoPeedyPeebles (talk) 18:45, 14 January 2009 (UTC)

External links

Wikipedia's external links policy and the specific guidelines for medicine-related articles do not permit the inclusion of external links to non-encyclopedic material, particularly including: patient support groups, personal experience/survivor stories, internet chat boards, e-mail discussion groups, recruiters for clinical trials, healthcare providers, fundraisers, or similar pages.

Wikipedia is an encyclopedia, not an advertising opportunity or a support group for patients or their families. Please do not re-insert links that do not conform to the standard rules.

External links are not required in Wikipedia articles. They are permitted in limited numbers and in accordance with the policies linked above. If you want to include one or more external links in this article, please link directly to a webpage that provides detailed, encyclopedic information about the disease. Thanks, WhatamIdoing (talk) 04:27, 13 April 2008 (UTC)

I've removed another link to rareshare.org. WP:ELNO specifically bans links to internet discussion forums. Such links will always be removed. WhatamIdoing (talk) 18:45, 11 August 2008 (UTC)

Guidelines

2002 guidelines: PMID 12213843 JFW | T@lk 07:00, 30 July 2008 (UTC)

Antonio Silva suffers from this disease and recently had surgery. His Elite XC world heavyweight atm and should be included. Intresting to note he was accused of taking steroids even though they would kill someone with this disease. —Preceding unsigned comment added by 124.171.81.173 (talk) 12:30, 22 August 2008 (UTC)

I don't see why my entries for Primo Carnera and Nikolai Valuev were deleted. You can easily see that they have this condition.

http://images.google.com/images?hl=en&q=primo%20carnera

http://images.google.com/images?um=1&hl=en&safe=off&q=nikolia+valuev —Preceding unsigned comment added by Urbanchampion (talk • contribs) 00:37, 21 January 2009 (UTC)

Normal people

Do many "normal people" show mild acromegalic changes as they age? Wnt (talk) 09:06, 26 November 2008 (UTC)

Yes, I grew six inches last week and I'm completely normal. --OhNoPeedyPeebles (talk) 20:19, 10 May 2009 (UTC)

Living people

We can't just list a bunch of names and assert that living people have a disease. Wikipedia's policies on writing about people absolutely demands reliable sources for information like this. Speculation and "I think I heard this on TV one day" are not good enough.

Furthermore, a long list of every person ever known to have a disease is just trivia, which is not encyclopedic.

So if you want to include someone's name here as a person living with this disease, then you need to first consider whether this person is really an important example of this disease (like Lou Gehrig was for Lou Gehrig's disease in America), and then provide a solid reliable source to demonstrate that they really do have this disease. This will help us comply with Wikipedia's policies. Thanks, WhatamIdoing (talk) 05:36, 31 January 2009 (UTC)

Tony Robbins certainly qualifies to be here: e.g. http://weirdtechnewshub.blogspot.com/2008/02/biography-tony-robbins.html 64.71.2.189 (talk) 21:33, 20 March 2012 (UTC)

Melmed

JCI - review on pathogenesis and treatment doi:10.1172/JCI39375 JFW | T@lk 14:28, 22 November 2009 (UTC)

Namigoro Rashomon

The character "Kannuki the giant" in Yojimbo is played by Namigoro Rashomon. Does anyone know whether he had (has?) acromegaly? —Preceding unsigned comment added by 132.206.92.205 (talk) 04:16, 21 January 2010 (UTC)

Acromegaly resulting from HGH use/abuse

Since HGH has become more commonly available by bodybuilders and professional athletes (and Carrot Top, seriously), its use should be mentioned as a cause of Acromegaly. —Preceding unsigned comment added by 75.198.241.132 (talk) 21:40, 18 May 2010 (UTC)

Kevyn Aucoin was also less than 2 meters tall so that little note should probably be deleted. —Preceding unsigned comment added by 71.57.154.36 (talk) 06:29, 23 May 2010 (UTC)

Race

Does acromegaly affect races other than whites? I have never seen a black person with acromegaly. — Preceding unsigned comment added by 67.85.3.79 (talk) 06:03, 19 May 2012 (UTC)

Can we say true disfigurement? Is there a refrence for the definition of said disfigurement? I don't find any of the pictures of the people shown to be terribly unattractive by any means of the stretch. Need a citation as disfigurement is defined as using wikipedia itself:

"Disfigurement is the state of having one's appearance deeply and persistently harmed medically, as from a disease, birth defect, or wound."

I just don't see it...

Need Citation of "severe disfigurement"

Can we say true disfigurement? Is there a reference for the definition of said disfigurement? I don't find any of the pictures of the people shown to be terribly unattractive by any means of the stretch. Need a citation as disfigurement is defined as using wikipedia itself:

"Disfigurement is the state of having one's appearance deeply and persistently harmed medically, as from a disease, birth defect, or wound."

I just don't see it... — Preceding unsigned comment added by 67.11.173.196 (talk) 23:58, 21 August 2013 (UTC)

Proposed new classification

doi:10.1210/jc.2014-2468 - technically a primary source, so a secondary source for validation may still be needed. JFW | T@lk 12:27, 28 September 2014 (UTC)

Guideline

doi:10.1210/jc.2014-2700 - new Endocrine Society guideline.

doi:10.1210/jc.2014-2900 - meta analysis; surgical interventions may help but the data is low quality. JFW | T@lk 07:50, 2 November 2014 (UTC)

Other tumours

The final sentence in this section uses the word 'hypoglycoma'. As a lowly med student, I'm loathe to correct the article as it stands but as I'm not getting any google hits, is this a typo or am I missing something? — Preceding unsigned comment added by 91.235.65.22 (talk) 13:39, 12 January 2015 (UTC)

Very old vandalism, reverted. Thanks, Avb 22:04, 26 February 2017 (UTC)

I will just mention that Novartis received approval by FDA and EU for pasireotide (trade name Signifor) as a treatment for acromegaly, in injectable suspension for IM use, for patients that have had an inadequate response to surgery or for whom surgery is not an option. I have no ties to Novartis and came across this incidentally.Danleywolfe (talk) 02:29, 30 January 2016 (UTC)

Past historical cases of acromegaly or individuals from history suspected of having it.

Adding a section about figures from history that are suspected of having had acromegaly would be a nice addition. I heard on a program on The History Channel that Goliath from the Biblical tale of David and Goliath is suspected to have had the condition. It is also likely possible that many accounts (true or not) of ogres that terrorized people in Europe may have been individuals with the condition. — Preceding unsigned comment added by Jabs9950 (talk • contribs) 21:33, 23 April 2016 (UTC)

Goliath is pretty much a fictional character. As far as I know there is no extrabiblical evidence of his existence. I would oppose such a section as it would be based on crappy sources, and nothing but speculation. Jytdog (talk) 01:51, 24 April 2016 (UTC)

On July 20,2016 I added a citation needed tag to the inclusion of Ted Cassidy in the Notable cases section. I have been unable to find a credible source that Mr. Cassidy had been diagnosed with this condition. There are a number of sites that express the "supposition" that based on his height and facial features that he had acromegaly. There are a number of conditions that would cause similar facial features and, many individuals with acromegaly are of normal height. It's been over 10 weeks since a citation needed tag was added to the statement that Mr. Cassidy had acromegaly. As none has been provided I am removing this statement. Cbs527 (talk) 19:09, 1 October 2016 (UTC)

Wording

"Diagnosis is by measuring growth hormone after a person has drunk a glucose solution" was perfectly fine IMO and provides more information that "is administered" Doc James (talk · contribs · email) 16:54, 30 April 2019 (UTC)

Were does the ref say "suspected by finding an elevated blood insulin-like growth factor I" or "The mutation permanently switches on the signal for cell division and growth hormone secretion. " Doc James (talk · contribs · email) 07:08, 1 May 2019 (UTC)

Some contents topics are repeated

e.g. "Treatment", "Diagnosis" 62.74.17.185 (talk) 08:49, 14 August 2023 (UTC)